Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13242911 | 0.82 | P2RX7 (0.65) | ALDH1A1HPGDGAAL3MBTL1MAP2K1 | |
| SCHEMBL28589136 | 0.80 | POLB (0.64) | SMN1; SMN2LMNAALDH1A1HPGDNPC1 | |
| SCHEMBL29516862 | 0.80 | POLB (0.64) | SMN1; SMN2LMNAALDH1A1HPGDNPC1 | |
| SCHEMBL24003686 | 0.79 | P2RX7 (0.64) | SMN1; SMN2LMNAALDH1A1HPGDNPC1 | |
| SCHEMBL13242904 | 0.79 | P2RX7 (0.42) | SMN1; SMN2ALDH1A1HPGDGAAMAP2K1 | |
| SCHEMBL13207202 | 0.79 | LMNA (0.40) | SMN1; SMN2LMNAALDH1A1HPGDTDP1 | |
| SCHEMBL9703918 | 0.79 | HDAC3 (0.47) | NPC1MAP2K1MEN1KMT2A | |
| SCHEMBL28347782 | 0.77 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAALDH1A1HPGDNPC1 | |
| SCHEMBL28350738 | 0.77 | POLB (0.64) | SMN1; SMN2LMNAALDH1A1TDP1POLB | |
| SCHEMBL13242909 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAHPGDL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2160391-B1 | NICOTINAMIDE DERIVATIVES AS SYNTHESIS UNITS FOR PRODUCING AGROCHEMICAL SUBSTANCES, AND METHOD FOR THE PRODUCTION THEREOF | BAYER CROPSCIENCE AG (DE) | 2010-08-04 | — | — | EP | disclosed |
| EP-2160391-B1 | NICOTINAMIDE DERIVATIVES AS SYNTHESIS UNITS FOR PRODUCING AGROCHEMICAL SUBSTANCES, AND METHOD FOR THE PRODUCTION THEREOF | BAYER CROPSCIENCE AG (DE) | 2010-08-04 | — | — | EP | disclosed |
| US-20100190992-A1 | Nicotinamide derivatives as synthesis units for producing agrochemical substances, and method for the production thereof | BAYER CROPSCIENCE AG (DE) | 2010-07-29 | — | — | US | disclosed |
| US-20100190992-A1 | Nicotinamide derivatives as synthesis units for producing agrochemical substances, and method for the production thereof | BAYER CROPSCIENCE AG (DE) | 2010-07-29 | — | — | US | disclosed |
| US-20100190992-A1 | Nicotinamide derivatives as synthesis units for producing agrochemical substances, and method for the production thereof | BAYER CROPSCIENCE AG (DE) | 2010-07-29 | — | — | US | disclosed |
| EP-2160391-A1 | NICOTINAMIDE DERIVATIVES AS SYNTHESIS UNITS FOR PRODUCING AGROCHEMICAL SUBSTANCES, AND METHOD FOR THE PRODUCTION THEREOF | Bayer CropScience AG (DE) | 2010-03-10 | — | — | EP | disclosed |
| EP-2014658-A1 | Nicotinamide derivatives and method for their manufacture | Bayer CropScience AG (DE) | 2009-01-14 | — | — | EP | disclosed |
| WO-2008155003-A1 | NICOTINAMIDE DERIVATIVES AS SYNTHESIS UNITS FOR PRODUCING AGROCHEMICAL SUBSTANCES, AND METHOD FOR THE PRODUCTION THEREOF | BAYER CROPSCIENCE AG (DE) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008155003-A1 | NICOTINAMIDE DERIVATIVES AS SYNTHESIS UNITS FOR PRODUCING AGROCHEMICAL SUBSTANCES, AND METHOD FOR THE PRODUCTION THEREOF | BAYER CROPSCIENCE AG (DE) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190992-A1 | Nicotinamide derivatives as synthesis units for producing agrochemical substances, and method for the production thereof | NAMPT, NQO1, NNT | SMN1; SMN2 2622/4885LMNA 2360/4885ALDH1A1 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.