Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29025242 | 0.89 | TSHR (0.48) | MAPTKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL29025281 | 0.89 | IKBKB (0.53) | — | |
| SCHEMBL29025244 | 0.89 | MEN1 (0.54) | MAPTKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL29025291 | 0.78 | TNNI3K (0.49) | PIP4K2ACCNE1CDK2 | |
| SCHEMBL29025274 | 0.76 | IKBKB (0.48) | KMT2AALDH1A1MEN1SMN1; SMN2USP2 | |
| SCHEMBL29025269 | 0.76 | KMT2A (0.55) | MAPTKMT2AALDH1A1MEN1GAA | |
| SCHEMBL4170371 | 0.73 | TGFBR1 (0.71) | MAPTKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL15953254 | 0.72 | HTT (0.75) | KMT2AALDH1A1MEN1SMN1; SMN2GAA | |
| SCHEMBL2112295 | 0.72 | USP2 (0.76) | MAPTKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL1518644 | 0.71 | ALDH1A1 (0.48) | MAPTKMT2AALDH1A1MEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115160298-B | Tacrine-sulfonamide derivative and preparation method and application thereof | 中国人民解放军北部战区总医院 | 2023-05-23 | — | — | CN | disclosed |