Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29025244 | 0.87 | MEN1 (0.54) | KMT2AMEN1GAAALDH1A1MAPT | |
| SCHEMBL29025274 | 0.87 | IKBKB (0.48) | KMT2AMEN1ATMALDH1A1PKM | |
| SCHEMBL30565226 | 0.81 | ROCK1 (0.64) | KMT2AMEN1ATMGAAALDH1A1 | |
| SCHEMBL30023094 | 0.81 | KMT2A (0.65) | KMT2AMEN1ATMGAAALDH1A1 | |
| SCHEMBL12517875 | 0.78 | TNNI3K (0.70) | — | |
| SCHEMBL100316 | 0.78 | ALDH1A1 (0.62) | KMT2AMEN1GAAALDH1A1MAPT | |
| SCHEMBL3458402 | 0.77 | JAK2 (0.56) | KMT2AMEN1ATMGAAALDH1A1 | |
| SCHEMBL29025262 | 0.76 | MAPT (0.49) | KMT2AMEN1GAAALDH1A1MAPT | |
| SCHEMBL4181489 | 0.76 | TGFBR1 (0.58) | KMT2AMEN1ATMALDH1A1ERBB2 | |
| SCHEMBL3621519 | 0.75 | MEN1 (0.48) | KMT2AMEN1ATMGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115160298-B | Tacrine-sulfonamide derivative and preparation method and application thereof | 中国人民解放军北部战区总医院 | 2023-05-23 | — | — | CN | disclosed |