SCHEMBL29025875

SCHEMBL29025875

CCC(CC)(OP(=O)(O)O)C(=O)Nc1ccc(N=CN(C)C)c(C#N)c1

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 2/20 0.40
S1PR3 Q99500 2/20 0.40
ALDH1A1 P00352 1/20 0.33
AR P10275 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22076875 0.82 NPC1 (0.37) S1PR1S1PR3ALDH1A1
SCHEMBL22076876 0.82 NPC1 (0.37) S1PR1S1PR3ALDH1A1
SCHEMBL20605289 0.77 ALDH1A1 (0.40) ALDH1A1
SCHEMBL20605293 0.77 ALDH1A1 (0.40) ALDH1A1
SCHEMBL29025878 0.76 ALDH1A1 (0.38) ALDH1A1
SCHEMBL30478696 0.76 ALDH1A1 (0.38) ALDH1A1
SCHEMBL19322331 0.74 ALDH1A1 (0.38) ALDH1A1
SCHEMBL2249233 0.74 IMPDH2 (0.36) ALDH1A1
SCHEMBL24167727 0.73 EGFR (0.40) ALDH1A1
SCHEMBL6588041 0.73 EGFR (0.40) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109422755-B Nitrogen-containing heterocyclic compound, preparation method, intermediate, composition and application 上海医药集团股份有限公司 2023-07-04 CN disclosed