SCHEMBL29028658

SCHEMBL29028658

COCCN(C(=O)c1ccccc1)c1cccc(C(=O)Nc2c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2C(F)(F)F)c1F

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PTGES O14684 6/20 0.36
GPBAR1 Q8TDU6 2/20 0.36
KCNK3 O14649 2/20 0.34
KCNK9 Q9NPC2 2/20 0.34
RXFP1 Q9HBX9 3/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
KDM4E B2RXH2 1/20 0.33
HPGD P15428 1/20 0.33
TP53 P04637 1/20 0.33
HTT P42858 1/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
HDAC8 Q9BY41 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29114034 0.95 PTGES (0.35) PTGESGPBAR1KCNK3KCNK9RXFP1
SCHEMBL29028501 0.94 GPBAR1 (0.34) PTGESGPBAR1RXFP1KDM4EHPGD
SCHEMBL29114041 0.94 GPBAR1 (0.36) PTGESGPBAR1RXFP1MEN1KMT2A
SCHEMBL29114043 0.93 CTSS (0.35) PTGESGPBAR1KCNK3KCNK9RXFP1
SCHEMBL29114030 0.91 RXFP1 (0.35) PTGESGPBAR1RXFP1KDM4E
SCHEMBL28630497 0.91 MLYCD (0.36) KCNK3KCNK9RXFP1MEN1KMT2A
SCHEMBL31679336 0.90 TSHR (0.38) PTGESKCNK3KCNK9RXFP1MEN1
SCHEMBL28621340 0.90 TSHR (0.38) PTGESKCNK3KCNK9RXFP1MEN1
SCHEMBL29114026 0.90 HPGD (0.34) PTGESKCNK3KCNK9RXFP1MEN1
SCHEMBL29114033 0.90 PTGES (0.34) PTGESGPBAR1RXFP1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4610251-A1 HEPTAFLUOROISOPROPYL-CONTAINING BISAMIDE COMPOUND AND INTERMEDIATE COMPOUND THEREOF, AND PREPARATION METHODS THEREFOR AND USE THEREOF Zhejiang Udragon Pesticides And Chemicals Co., Ltd. (CN) 2025-09-03 EP disclosed
CN-116947679-A Bisamide compound containing sevoflurane isopropyl, and preparation method and application thereof 浙江宇龙药业有限公司 2023-10-27 CN disclosed
CN-115925576-B Bisamide compound containing sevoflurane isopropyl, and preparation method and application thereof 浙江宇龙药业有限公司 2023-08-08 CN disclosed
CN-115974717-A Heptafluoroisopropyl-containing bisamide compound and intermediate compound thereof, and preparation method and application thereof 浙江宇龙药业有限公司 2023-04-18 CN disclosed
CN-115925576-A Heptafluoroisopropyl-containing bisamide compound and preparation method and application thereof 浙江宇龙药业有限公司 2023-04-07 CN disclosed