Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamic Acid SCHEMBL1873097 | 0.90 | SLC1A3 (0.53) | KMT2AALDH1A1CYP2D6MAPK1KIF11 | |
| Glutamic Acid SCHEMBL5196110 | 0.90 | SLC1A3 (0.53) | KMT2AALDH1A1CYP2D6MAPK1KIF11 | |
| D-Glutamate SCHEMBL5196106 | 0.90 | SLC1A3 (0.53) | KMT2AALDH1A1CYP2D6MAPK1KIF11 | |
| Glutamine SCHEMBL31412743 | 0.87 | ALOX15 (0.59) | ALOX15BLMPMP22KMT2AKIF11 | |
| Norvaline SCHEMBL22749321 | 0.85 | KIF11 (0.47) | PMP22ALDH1A1CYP2D6MAPK1KIF11 | |
| SCHEMBL18075129 | 0.82 | KIF11 (0.48) | ALDH1A1CYP2D6MAPK1KIF11L3MBTL1 | |
| Glutamic Acid SCHEMBL4697460 | 0.82 | KIF11 (0.45) | ALDH1A1CYP2D6MAPK1KIF11L3MBTL1 | |
| D-Glutamate SCHEMBL7902663 | 0.82 | KIF11 (0.45) | ALDH1A1CYP2D6MAPK1KIF11L3MBTL1 | |
| D-Glutamate SCHEMBL4692007 | 0.82 | KIF11 (0.45) | ALDH1A1CYP2D6MAPK1KIF11L3MBTL1 | |
| Lysine SCHEMBL6683158 | 0.82 | GSR (0.56) | CYP2D6MAPK1KIF11SLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116333294-B | Catalyst for preparing block polyether and preparation method of block polyether | 辽宁奥克药业股份有限公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-116333294-A | Catalyst for preparing block polyether and preparation method of block polyether | 辽宁奥克药业股份有限公司 | 2023-06-27 | — | — | CN | disclosed |