Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 17/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.37 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27844984 | 0.88 | PLA2G2A (0.49) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL29029772 | 0.85 | ADRA1D (0.45) | PLA2G2AMAPK8PLA2G1B | |
| SCHEMBL29029778 | 0.85 | ATM (0.43) | MAPK8PLA2G1B | |
| SCHEMBL30410494 | 0.84 | PLA2G2A (0.54) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL817940 | 0.84 | PLA2G2A (0.54) | PLA2G2APLA2G1BPLA2G10PLA2G5PLA2G2E | |
| SCHEMBL29029764 | 0.83 | FEN1 (0.43) | — | |
| SCHEMBL6688540 | 0.82 | F10 (0.46) | PLA2G2AMAPK8PLA2G1BPLA2G10F10 | |
| SCHEMBL29029776 | 0.81 | MEN1 (0.41) | PLA2G2AMAPK8PLA2G1BPLA2G10PLA2G5 | |
| SCHEMBL30411505 | 0.81 | MAPK8 (0.42) | PLA2G2AMAPK8PLA2G1BPLA2G10F10 | |
| SCHEMBL29029762 | 0.81 | MAPK8 (0.42) | PLA2G2AMAPK8PLA2G1BPLA2G10F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116585306-A | PLA2 inhibitors for immediate treatment of hymenoptera toxicity and other conditions due to histamine release | 奥菲瑞克斯股份有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-109562098-B | PLA2 inhibitors for immediate treatment of hymenoptera toxicity and other conditions due to histamine release | 奥菲瑞克斯股份有限公司 | 2023-04-21 | — | — | CN | disclosed |