Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL818699 | 0.85 | PLA2G2A (0.52) | ADRA1DCCR2PLA2G2APLA2G1B | |
| SCHEMBL29862301 | 0.85 | PLA2G2A (0.52) | ADRA1DCCR2PLA2G2APLA2G1B | |
| SCHEMBL27844984 | 0.85 | PLA2G2A (0.49) | PLA2G2APLA2G1B | |
| SCHEMBL29029784 | 0.85 | PLA2G2A (0.40) | MAPK8PLA2G2APLA2G1B | |
| SCHEMBL6699063 | 0.83 | ADRA1D (0.49) | ADRA1DKLKB1KLK1MAPK8CCR2 | |
| SCHEMBL30409266 | 0.82 | ADRA1D (0.48) | ADRA1DKLKB1KLK1MAPK8CCR2 | |
| SCHEMBL29029771 | 0.82 | ADRA1D (0.48) | ADRA1DKLKB1KLK1MAPK8CCR2 | |
| SCHEMBL29029778 | 0.82 | ATM (0.43) | MAPK8FEN1SIRT2PLA2G1B | |
| SCHEMBL7054203 | 0.81 | ADRA1D (0.49) | ADRA1DKLKB1KLK1MAPK8CCR2 | |
| SCHEMBL7967330 | 0.81 | PLA2G2A (0.52) | ADRA1DKLKB1KLK1CCR2PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116585306-A | PLA2 inhibitors for immediate treatment of hymenoptera toxicity and other conditions due to histamine release | 奥菲瑞克斯股份有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-109562098-B | PLA2 inhibitors for immediate treatment of hymenoptera toxicity and other conditions due to histamine release | 奥菲瑞克斯股份有限公司 | 2023-04-21 | — | — | CN | disclosed |