Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23014998 | 0.82 | CYP19A1 (0.42) | LOXL2CYP2A6CYP19A1MAOBKMT2A | |
| SCHEMBL2903299 | 0.81 | HRH3 (0.50) | HRH3CYP19A1DAOKMT2A | |
| SCHEMBL6944017 | 0.77 | CYP3A4 (0.48) | HRH3LOXL2CYP19A1MAOB | |
| SCHEMBL1818072 | 0.77 | — | — | |
| SCHEMBL28117639 | 0.77 | ESR1 (0.48) | — | |
| SCHEMBL29272 | 0.76 | ALDH1A1 (0.46) | HRH3MAOBKMT2A | |
| Benzene SCHEMBL27499662 | 0.76 | ALDH1A1 (0.46) | HRH3MAOBKMT2A | |
| SCHEMBL9508013 | 0.74 | ALDH1A1 (0.44) | HRH3MAOBKMT2A | |
| SCHEMBL3918469 | 0.74 | LTA4H (0.48) | KMT2A | |
| SCHEMBL28326701 | 0.74 | HTR1D (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1049157-A | The preparation method of cycloalkanylpyrrole | SCHERING AG (DE) | 1991-02-13 | — | — | CN | claimed |
| EP-0490816-B1 | Fluoro-compounds and their use as aromatase inhibitors | CIBA GEIGY AG (CH) | 1997-07-09 | — | — | EP | disclosed |
| US-5637605-A | ANTITUMOR AGENTS | CIBA GEIGY CORPORATION (US) | 1997-06-10 | — | — | US | disclosed |
| US-5583128-A | ADMINISTERING A SIDE EFFECT REDUCED AROMATASE INHIBITOR | CIBA-GEIGY CORPORATION (US) | 1996-12-10 | — | — | US | disclosed |
| US-5457209-A | Antitumor agents | CIBA-GEIGY CORPORATION (US) | 1995-10-10 | — | — | US | disclosed |
| EP-0411735-B1 | Cycloalkylenazoles, process for their preparation, pharmaceutical preparations containing them and their use for the preparation of medicines | SCHERING AG (DE) | 1995-05-17 | — | — | EP | disclosed |
| US-5411982-A | Cycloalkylene azoles, and their use as aromatase inhibitors | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-05-02 | — | — | US | disclosed |
| US-5376669-A | Antitumor agents | CIBA-GEIGY CORP. (US) | 1994-12-27 | — | — | US | disclosed |
| CN-1024345-C | Process for preparing cycloalkanylpyrrole | SCHERING AG (DE) | 1994-04-27 | — | — | CN | disclosed |
| US-5280035-A | Cycloalkylene azoles and their use as aromatase inhibitors | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-01-18 | — | — | US | disclosed |
| US-5227393-A | estrogen-dependent diseases, anticancer | CIBA-GEIGY CORPORATION (US) | 1993-07-13 | — | — | US | disclosed |
| US-5135937-A | Aromatase inhibitors | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0490816-A2 | Fluoro-compounds | CIBA-GEIGY AG (CH) | 1992-06-17 | — | — | EP | disclosed |
| WO-1991001975-A1 | CYCLOALKYLENAZOLES, PROCESS FOR PREPARING THEM, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE TO MANUFACTURE DRUGS | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1991-02-21 | — | — | WO | disclosed |
| CN-1049157-A | The preparation method of cycloalkanylpyrrole | SCHERING AG (DE) | 1991-02-13 | — | — | CN | disclosed |
| EP-0411735-A1 | Cycloalkylenazoles, process for their preparation, pharmaceutical preparations containing them and their use for the preparation of medicines | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-02-06 | — | — | EP | disclosed |