Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28382326 | 0.88 | PIM1 (0.40) | CHEK1CCNE1CDK2 | |
| SCHEMBL28886993 | 0.84 | SRPK1 (0.43) | IRAK4 | |
| SCHEMBL28383473 | 0.83 | PIM1 (0.39) | CHEK1CCNE1CDK2 | |
| SCHEMBL28382783 | 0.82 | CHEK1 (0.51) | CHEK1IRAK4 | |
| SCHEMBL29033317 | 0.79 | AKT1 (0.41) | IRAK4 | |
| SCHEMBL28887910 | 0.79 | PIM1 (0.41) | IRAK4 | |
| SCHEMBL20598346 | 0.77 | CHEK1 (0.60) | CHEK1CCNE1CDK2IRAK4 | |
| SCHEMBL15071640 | 0.75 | CHEK1 (0.84) | CHEK1 | |
| SCHEMBL28383196 | 0.75 | CHEK1 (0.52) | CHEK1IRAK4 | |
| SCHEMBL20598108 | 0.75 | CHEK1 (0.57) | CHEK1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032642-B | Kinase inhibitors and methods of making and using the same | 里格尔药品股份有限公司 | 2023-07-18 | — | — | CN | claimed |
| CN-111032642-B | Kinase inhibitors and methods of making and using the same | 里格尔药品股份有限公司 | 2023-07-18 | — | — | CN | disclosed |