Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | POLB | P06746 | 9/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26227598 | 0.86 | HTT (0.56) | NPC1RAB9APOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL4738386 | 0.82 | DUT (0.35) | TDP1POLBSMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL4741957 | 0.79 | ALDH1A1 (0.44) | KMT2AMAPTALDH1A1 | |
| SCHEMBL12144860 | 0.78 | ALDH1A1 (0.37) | TDP1NPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL3257255 | 0.78 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL1361805 | 0.78 | CHRM2 (0.40) | TDP1POLBL3MBTL1KMT2AMAPT | |
| SCHEMBL4741404 | 0.77 | CYP4F2 (0.36) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL3183932 | 0.76 | ALDH1A1 (0.35) | NPC1RAB9ASMN1; SMN2MAPK1KMT2A | |
| SCHEMBL12144858 | 0.76 | ALDH1A1 (0.46) | NPC1RAB9APOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL21654079 | 0.74 | TDP1 (0.56) | TDP1NPC1RAB9APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116390920-A | Aromatic spirocyclic amide derivatives for the treatment and prevention of hepatitis b virus infection | 豪夫迈·罗氏有限公司 | 2023-07-04 | — | — | CN | disclosed |