SCHEMBL4741404

SCHEMBL4741404

COC(=O)Cc1ccc(CCO[Si](C)(C)C(C)(C)C)o1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 1/20 0.36
CYP4A11 Q02928 1/20 0.36
HSP90AB1 P08238 1/20 0.34
ALDH1A1 P00352 4/20 0.33
DUT P33316 2/20 0.33
GAA P10253 2/20 0.33
KDM4E B2RXH2 2/20 0.33
GLA P06280 2/20 0.33
BACE1 P56817 1/20 0.33
TSHR P16473 1/20 0.33
GFER P55789 1/20 0.33
HTT P42858 2/20 0.33
HPGD P15428 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
MAPT P10636 2/20 0.32
LMNA P02545 1/20 0.32
NPC1 O15118 1/20 0.32
TP53 P04637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4738386 0.86 DUT (0.35) ALDH1A1DUTKDM4EBACE1HTT
SCHEMBL26227598 0.81 HTT (0.56) ALDH1A1KDM4ETSHRHTTHPGD
SCHEMBL12144860 0.79 ALDH1A1 (0.37) ALDH1A1DUTKDM4ETSHRHPGD
SCHEMBL3257255 0.79 ALDH1A1 (0.36) ALDH1A1DUT
SCHEMBL17581887 0.78 HSP90AB1 (0.50) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL3183932 0.77 ALDH1A1 (0.35) ALDH1A1DUTGAAKDM4EHTT
SCHEMBL29033401 0.77 TDP1 (0.47) ALDH1A1KDM4EHTTSMN1; SMN2MAPT
SCHEMBL1361805 0.76 CHRM2 (0.40) ALDH1A1DUTKDM4EGLATSHR
SCHEMBL4741136 0.76 CYP4F2 (0.56) CYP4F2CYP4A11HSP90AB1ALDH1A1GAA
SCHEMBL5406240 0.74 CYP4A11 (0.51) CYP4F2CYP4A11HSP90AB1ALDH1A1DUT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008149110-A1 BICYCLOR [2.2.1] HEPT-7-YLAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASES AND CONDITIONS IN WHICH M3 MUSCARINIC RECEPTOR ACTIVITY AND BETA-ADRENERGIC ACTIVITY ARE IMPLICATED ARGENTA DISCOVERY LIMITED (GB) 2008-12-11 WO disclosed
WO-2008096129-A1 NITROGEN CONTAINING HETROCYCLIC COMPOUNDS USEFUL AS BIFUNCTIONAL MODULATORS OF M3 RECEPTORS AND BETA- 2 RECEPTORS ARGENTA DISCOVERY LTD (GB) 2008-08-14 WO disclosed
WO-2008096127-A2 BICYCLO[2.2.1]HEPT-7-YLAMINE DERIVATIVES AND THEIR USE AS M3 MUSCARINIC RECEPTOR MODULATORS ARGENTA DISCOVERY LTD (GB) 2008-08-14 WO disclosed