Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ASPH | Q12797 | 2/20 | 0.47 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.47 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.47 |
| ▸ | VNN1 | O95497 | 3/20 | 0.44 |
| ▸ | FYN | P06241 | 4/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203576 | 0.87 | DHODH (0.49) | VNN1ALDH1A1HPGDPPARAMAPT | |
| SCHEMBL1202935 | 0.87 | P4HTM (0.47) | KDM4EFYNPPARAMAPTADORA3 | |
| SCHEMBL1202234 | 0.85 | KDM4E (0.47) | KDM4EASPHKDM8RIOX2CHRM4 | |
| SCHEMBL1203014 | 0.85 | DHODH (0.41) | KDM4EFYNCHRM4ALDH1A1PKM | |
| SCHEMBL2903422 | 0.83 | MMP13 (0.43) | VNN1FYNCHRM4PPARA | |
| SCHEMBL1203745 | 0.82 | PPARD (0.46) | ALDH1A1HPGDMAPT | |
| SCHEMBL1203600 | 0.81 | FYN (0.59) | KDM4EASPHKDM8RIOX2VNN1 | |
| SCHEMBL2905633 | 0.81 | HDAC3 (0.46) | FYNADORA3 | |
| SCHEMBL1203495 | 0.80 | ALDH1A1 (0.43) | VNN1ALDH1A1HPGDMAPT | |
| SCHEMBL1202941 | 0.79 | KMT2A (0.47) | ALDH1A1PKMHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217601-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060197-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2009-05-14 | — | — | WO | disclosed |