Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | CTSC | P53634 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.30 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290586 | 0.85 | CTSC (0.34) | CTSCKCNH2LTB4RLTB4R2 | |
| SCHEMBL2893107 | 0.78 | TACR2 (0.40) | — | |
| SCHEMBL2893105 | 0.78 | TACR2 (0.40) | — | |
| SCHEMBL2890517 | 0.76 | CTSC (0.48) | RETCTSCKCNH2LTB4RLTB4R2 | |
| SCHEMBL2890519 | 0.76 | CTSC (0.48) | RETCTSCKCNH2LTB4RLTB4R2 | |
| SCHEMBL290369 | 0.75 | GHSR (0.32) | GHSRRET | |
| SCHEMBL16485828 | 0.68 | GRB2 (0.40) | — | |
| SCHEMBL16478335 | 0.68 | GRB2 (0.40) | — | |
| SCHEMBL16478334 | 0.68 | GRB2 (0.40) | — | |
| SCHEMBL7223168 | 0.68 | KLK5 (0.45) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427445-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | AstraZeneca AB (SE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128324-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | ASTRAZENECA AB (SE) | 2010-11-11 | — | — | WO | disclosed |