Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 2/20 | 0.34 |
| ▸ | TACR2 | P21452 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.30 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290368 | 0.85 | GHSR (0.35) | CTSCKCNH2LTB4RLTB4R2 | |
| SCHEMBL300375 | 0.82 | CTSC (0.34) | CTSCKCNH2LTB4RLTB4R2 | |
| SCHEMBL289266 | 0.78 | CTSC (0.47) | CTSCKCNH2LTB4RLTB4R2 | |
| SCHEMBL290581 | 0.75 | TACR2 (0.45) | CTSCTACR2 | |
| SCHEMBL288761 | 0.72 | CTSC (0.56) | CTSCTACR2KCNH2LTB4RLTB4R2 | |
| SCHEMBL289882 | 0.71 | CTSC (0.32) | CTSCKCNH2LTB4RLTB4R2HIF1A | |
| SCHEMBL290587 | 0.71 | TACR2 (0.32) | TACR2 | |
| SCHEMBL289883 | 0.65 | CTSL (0.37) | CTSCTACR2KCNH2LTB4RLTB4R2 | |
| SCHEMBL16478069 | 0.64 | TACR2 (0.45) | TACR2 | |
| SCHEMBL16478172 | 0.63 | TACR2 (0.45) | TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427445-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | AstraZeneca AB (SE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128324-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | ASTRAZENECA AB (SE) | 2010-11-11 | — | — | WO | disclosed |