Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | NAAA | Q02083 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19830587 | 1.00 | LMNA (0.60) | LMNAPOLBSMN1; SMN2L3MBTL1NAAA | |
| SCHEMBL5935756 | 1.00 | LMNA (0.60) | LMNAPOLBSMN1; SMN2L3MBTL1NAAA | |
| SCHEMBL5935769 | 0.98 | LMNA (0.58) | LMNAPOLBSMN1; SMN2L3MBTL1NAAA | |
| SCHEMBL5405182 | 0.98 | SMN1; SMN2 (0.62) | LMNAPOLBSMN1; SMN2L3MBTL1NAAA | |
| SCHEMBL10700528 | 0.96 | SMN1; SMN2 (0.60) | LMNAPOLBSMN1; SMN2L3MBTL1NAAA | |
| SCHEMBL1859157 | 0.92 | SMN1; SMN2 (0.69) | LMNAPOLBSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL6129170 | 0.92 | POLB (0.64) | LMNAPOLBSMN1; SMN2NAAANPSR1 | |
| SCHEMBL7838421 | 0.91 | SMN1; SMN2 (0.67) | LMNAPOLBSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL11492059 | 0.91 | SMN1; SMN2 (0.67) | LMNAPOLBSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL1826048 | 0.91 | SMN1; SMN2 (0.67) | LMNAPOLBSMN1; SMN2L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117285547-A | Macrocyclic compounds as modulators of CFTR, pharmaceutical compositions thereof, their use and methods of preparation | 弗特克斯药品有限公司 | 2023-12-26 | — | — | CN | disclosed |
| CN-112004817-B | Macrocyclic compounds as modulators of CFTR, pharmaceutical compositions thereof, their use and methods of preparation | 弗特克斯药品有限公司 | 2023-06-23 | — | — | CN | disclosed |