Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.50 |
| ▸ | TOP2A | P11388 | 6/20 | 0.45 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747727 | 0.87 | KCNH2 (0.52) | KCNH2TOP2ATOP2BGSK3BKDM4E | |
| SCHEMBL2081998 | 0.86 | ADRB2 (0.45) | KCNH2GSK3BHPGDALOX15TDP1 | |
| SCHEMBL12665502 | 0.85 | KCNH2 (0.53) | KCNH2TOP2ATOP2BGSK3BKDM4E | |
| SCHEMBL28087665 | 0.82 | KCNH2 (0.35) | KCNH2TOP2ATOP2BGSK3B | |
| SCHEMBL3720416 | 0.80 | TOP2A (0.58) | KCNH2TOP2ATOP2BGSK3BKDM4E | |
| SCHEMBL4714357 | 0.80 | KDM4E (0.49) | KCNH2TOP2ATOP2BGSK3BKDM4E | |
| SCHEMBL5734714 | 0.79 | TOP2A (0.57) | KCNH2TOP2ATOP2BGSK3BKDM4E | |
| Fluoride SCHEMBL5142576 | 0.78 | TOP2A (0.56) | KCNH2TOP2ATOP2BGSK3BKDM4E | |
| SCHEMBL10330779 | 0.78 | TOP2A (0.56) | KCNH2TOP2ATOP2BGSK3BKDM4E | |
| SCHEMBL2670762 | 0.78 | KCNH2 (0.46) | KCNH2TOP2ATOP2BGSK3BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105801482-A | Method for preparing 1-cyclopropyl-4-oxo-7-bromine-8-difluoromethoxy-1,4-dihydro-quinoline-3-nonanoic acid-ethyl ester | 浙江中欣氟材股份有限公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-105777631-A | Synthesizing method of 1-cyclopropyl-4-oxo-7-bromo-8-difluoromethoxy-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester | 浙江中欣氟材股份有限公司 | 2016-07-20 | — | — | CN | disclosed |
| EP-1031569-B1 | SALT OF A 7-ISOINDOLINEQUINOLONECARBOXYLIC ACID DERIVATIVE, MONOHYDRATE THEREOF AND COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDIENT | TOYAMA CHEMICAL CO LTD (JP) | 2010-03-17 | — | — | EP | disclosed |
| US-20090270379-A1 | QUINOLONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-10-29 | — | — | US | disclosed |
| WO-2009131973-A1 | QUINOLONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA NV (BE) | 2009-10-29 | — | — | WO | disclosed |
| EP-1336611-B1 | DEHALOGENO COMPOUNDS | DAIICHI SEIYAKU CO (JP) | 2007-09-05 | — | — | EP | disclosed |
| CN-1269817-C | Dehalogenated compounds | DAIICHI SEIYAKU CO (JP) | 2006-08-16 | — | — | CN | disclosed |
| CN-1486315-A | Dehalogenated compounds | ��һ��������ҩ��ʽ���� | 2004-03-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270379-A1 | QUINOLONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | NQO2, QARS1, NQO1 | KCNH2 3433/4885TOP2A 65/4885TOP2B 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.