Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 2/20 | 0.30 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.30 |
| ▸ | SCD | O00767 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2903740 | 0.82 | KCNH2 (0.50) | KCNH2GSK3BTOP2ATOP2B | |
| SCHEMBL27898679 | 0.71 | GSK3B (0.49) | KCNH2GSK3BTOP2ATOP2B | |
| SCHEMBL5734714 | 0.64 | TOP2A (0.57) | KCNH2GSK3BTOP2ATOP2B | |
| SCHEMBL13927305 | 0.63 | TOP2A (0.44) | KCNH2GSK3BTOP2ATOP2B | |
| SCHEMBL3720416 | 0.63 | TOP2A (0.58) | KCNH2GSK3BTOP2ATOP2BCHRM2 | |
| SCHEMBL27593515 | 0.61 | KCNH2 (0.53) | KCNH2GSK3BTOP2ATOP2BCHRM2 | |
| SCHEMBL4998742 | 0.61 | KCNH2 (0.46) | KCNH2GSK3BTOP2ATOP2B | |
| SCHEMBL5142579 | 0.61 | TOP2A (0.55) | KCNH2GSK3BTOP2ATOP2BCHRM2 | |
| SCHEMBL28774485 | 0.61 | MMP12 (0.35) | — | |
| SCHEMBL7507103 | 0.60 | ADRB2 (0.55) | KCNH2TOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105837555-A | Preparation method for garenoxacin and intermediate thereof | 南京华威医药科技开发有限公司 | 2016-08-10 | — | — | CN | disclosed |