Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29520120 | 1.00 | KDM4E (0.60) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29037795 | 0.87 | KDM4E (0.48) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29520312 | 0.87 | KDM4E (0.48) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5743284 | 0.85 | KDM4E (0.56) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30447855 | 0.82 | KDM4E (0.70) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14504072 | 0.82 | KDM4E (0.56) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29037742 | 0.82 | CCNA2 (0.50) | BRD4 | |
| SCHEMBL28717256 | 0.81 | KDM4E (0.62) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23444657 | 0.81 | XDH (0.46) | KDM4EL3MBTL1SMN1; SMN2MAPTLMNA | |
| SCHEMBL29520446 | 0.80 | KDM4E (0.41) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |