Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29520312 | 1.00 | KDM4E (0.48) | KDM4EKCNH2L3MBTL1NPC1RAB9A | |
| SCHEMBL29520120 | 0.87 | KDM4E (0.60) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29037680 | 0.87 | KDM4E (0.60) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29520519 | 0.87 | EML4 (0.47) | FGFR3ALDH1A1EGFR | |
| SCHEMBL29037754 | 0.87 | EML4 (0.47) | FGFR3ALDH1A1EGFR | |
| SCHEMBL29037743 | 0.84 | FGFR3 (0.53) | KDM4EKCNH2CDK4FGFR3EGFR | |
| SCHEMBL29520366 | 0.84 | FGFR3 (0.53) | KDM4EKCNH2CDK4FGFR3EGFR | |
| SCHEMBL29037744 | 0.80 | ALDH1A1 (0.46) | L3MBTL1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL29520314 | 0.79 | FGFR3 (0.55) | KCNH2CDK4FGFR3EGFR | |
| SCHEMBL29037679 | 0.79 | FGFR3 (0.55) | KCNH2CDK4FGFR3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |