Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10157382 | 0.87 | ALDH1A1 (0.44) | KDM4EALDH1A1L3MBTL1CDK4CCND1 | |
| SCHEMBL12848675 | 0.83 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL12464187 | 0.83 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1MAPTSMN1; SMN2CYP2D6 | |
| SCHEMBL12128903 | 0.81 | HPGD (0.52) | KDM4EALDH1A1MAPTSMN1; SMN2CYP1A2 | |
| SCHEMBL8736858 | 0.81 | MAPT (0.43) | ALDH1A1MAPTSMN1; SMN2LMNAHTR3E | |
| SCHEMBL10156732 | 0.81 | KDM4E (0.44) | KDM4EALDH1A1L3MBTL1MAPTNPC1 | |
| SCHEMBL5741642 | 0.80 | ALDH1A1 (0.44) | KDM4EALDH1A1L3MBTL1CDK4CCND1 | |
| SCHEMBL13816038 | 0.80 | MAPT (0.42) | KDM4EALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL6924885 | 0.78 | ALDH1A1 (0.69) | KDM4EALDH1A1L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL12082405 | 0.76 | ALDH1A1 (0.53) | KDM4EALDH1A1L3MBTL1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |