Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1641810 | 0.83 | MAPT (0.52) | MAPTDRD2ALDH1A1LMNAADRA1B | |
| SCHEMBL12464187 | 0.81 | ALDH1A1 (0.48) | MAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL29037852 | 0.80 | KDM4E (0.50) | MAPTALDH1A1LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL1642194 | 0.78 | ALDH1A1 (0.68) | MAPTALDH1A1LMNAKDM4ESLC6A9 | |
| SCHEMBL1725714 | 0.74 | ALDH1A1 (0.61) | MAPTALDH1A1LMNAKDM4ESLC6A9 | |
| SCHEMBL12848675 | 0.73 | ALDH1A1 (0.54) | MAPTALDH1A1SMN1; SMN2SLC6A9KMT2A | |
| SCHEMBL10157382 | 0.72 | ALDH1A1 (0.44) | ALDH1A1HTR1AKDM4E | |
| SCHEMBL12128903 | 0.71 | HPGD (0.52) | MAPTALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL8736858 | 0.71 | MAPT (0.43) | MAPTALDH1A1LMNASMN1; SMN2HTR7 | |
| SCHEMBL16026653 | 0.69 | SLC6A9 (0.56) | MAPTDRD2ALDH1A1LMNASLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076140-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |