Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30409799 | 1.00 | EGFR (0.49) | EGFRKDM4EALDH1A1MAPTCCNT1 | |
| SCHEMBL29039270 | 0.84 | EGFR (0.53) | EGFR | |
| SCHEMBL30409186 | 0.84 | EGFR (0.53) | EGFR | |
| SCHEMBL29039452 | 0.84 | EGFR (0.52) | EGFRKDM4EALDH1A1 | |
| SCHEMBL30410176 | 0.84 | EGFR (0.52) | EGFRKDM4EALDH1A1 | |
| SCHEMBL30410499 | 0.84 | KCNH2 (0.58) | EGFRKDM4EALDH1A1MAPTKCNH2 | |
| SCHEMBL29039428 | 0.84 | KCNH2 (0.58) | EGFRKDM4EALDH1A1MAPTKCNH2 | |
| SCHEMBL29039439 | 0.83 | PTGS2 (0.51) | EGFRKCNH2ACHETGFBR1 | |
| SCHEMBL30410597 | 0.83 | PTGS2 (0.51) | EGFRKCNH2ACHETGFBR1 | |
| SCHEMBL5822178 | 0.82 | EGFR (0.46) | EGFRKDM4EALDH1A1MAPTCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116143773-B | 2-amino-4-thiazolylpyrimidine compound and preparation method and application thereof | 中国药科大学 | 2023-07-21 | — | — | CN | disclosed |
| CN-116143773-A | 2-amino-4-thiazolylpyrimidine compound and preparation method and application thereof | 中国药科大学 | 2023-05-23 | — | — | CN | disclosed |