Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819549 | 0.84 | TGFBR1 (0.55) | EGFRKDM4EALDH1A1MAPTKCNH2 | |
| SCHEMBL30409799 | 0.82 | EGFR (0.49) | EGFRKDM4EALDH1A1MAPTCCNT1 | |
| SCHEMBL29039434 | 0.82 | EGFR (0.49) | EGFRKDM4EALDH1A1MAPTCCNT1 | |
| SCHEMBL5822172 | 0.82 | PTGS2 (0.41) | EGFRKCNH2TGFBR1 | |
| SCHEMBL5818004 | 0.79 | MEN1 (0.33) | KCNH2TGFBR1 | |
| SCHEMBL5818469 | 0.78 | KCNH2 (0.54) | EGFRALDH1A1KCNH2 | |
| SCHEMBL5819408 | 0.76 | KCNH2 (0.62) | KCNH2 | |
| SCHEMBL5817608 | 0.74 | CDK2 (0.43) | EGFRALDH1A1MAPTKCNH2 | |
| SCHEMBL5819799 | 0.73 | CCNT1 (0.45) | EGFRKDM4EALDH1A1MAPTCCNT1 | |
| SCHEMBL5819806 | 0.72 | MAPK13 (0.56) | EGFRCCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | disclosed |