Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | EIF4E | P06730 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.32 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 3/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | FLT3 | P36888 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2910444 | 0.92 | MAPT (0.35) | GSK3BGSK3AMEN1MITFKMT2A | |
| SCHEMBL2914083 | 0.91 | MET (0.35) | GSK3BGSK3AAXLSMN1; SMN2MERTK | |
| SCHEMBL2909796 | 0.91 | EIF4E (0.39) | GSK3BGSK3AEIF4EAXLTXNRD1 | |
| SCHEMBL2904943 | 0.91 | GSK3B (0.35) | GSK3BGSK3AAXLMEN1KMT2A | |
| SCHEMBL2905411 | 0.90 | GSK3B (0.35) | GSK3BGSK3AAXLMERTKCDK1 | |
| SCHEMBL2910908 | 0.90 | GSK3B (0.41) | GSK3BGSK3AMEN1MITFKMT2A | |
| SCHEMBL2912022 | 0.88 | GSK3B (0.34) | GSK3BGSK3AEIF4EAXLMERTK | |
| SCHEMBL2911914 | 0.88 | AHR (0.37) | GSK3BGSK3AEIF4EAXLMEN1 | |
| SCHEMBL2913577 | 0.88 | AHR (0.37) | GSK3BGSK3AEIF4EAXLMEN1 | |
| SCHEMBL2906883 | 0.87 | CFTR (0.38) | GSK3BGSK3AEIF4EAXLMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-B1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2010-08-11 | — | — | EP | disclosed |