Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 4/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29042384 | 0.87 | AHR (0.42) | AHRSLC6A2SLC6A4SLC6A3CYP2A6 | |
| SCHEMBL17863581 | 0.71 | MAPK1 (0.37) | MEN1MAPK1KMT2A | |
| SCHEMBL15566771 | 0.71 | AHR (0.50) | MEN1POLBMAPK1KMT2AAHR | |
| SCHEMBL17913415 | 0.70 | AHR (0.46) | MEN1POLBMAPK1KMT2AAHR | |
| SCHEMBL7864936 | 0.70 | TNKS (0.43) | MAPK1BRD4 | |
| SCHEMBL19235056 | 0.68 | MEN1 (0.47) | MEN1POLBMAPK1KMT2AAHR | |
| SCHEMBL30286426 | 0.68 | NOS1 (0.45) | MEN1POLBKMT2ASLC6A2SLC6A4 | |
| SCHEMBL17014397 | 0.67 | NPC1 (0.58) | KDM4EALDH1A1L3MBTL1CYP2D6 | |
| SCHEMBL9946120 | 0.67 | HTR2A (0.37) | ALDH1A1TDP1ESR1 | |
| SCHEMBL13718 | 0.67 | LPL (0.46) | MEN1POLBMAPK1KMT2AAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115279741-A | 4-phenyl-N- (phenyl) thiazol-2-amine derivatives and related compounds as Aryl Hydrocarbon Receptor (AHR) agonists for the treatment of, for example, angiogenesis-related disorders or inflammatory disorders | 医肯纳肿瘤学公司 | 2022-11-01 | — | — | CN | disclosed |