Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 2/20 | 0.42 |
| ▸ | GPR183 | P32249 | 4/20 | 0.42 |
| ▸ | CCR2 | P41597 | 3/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.40 |
| ▸ | ITGAL | P20701 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2904266 | 1.00 | PYGL (0.42) | PYGLGPR183CCR2ITGB2ICAM1 | |
| SCHEMBL2904260 | 1.00 | PYGL (0.42) | PYGLGPR183CCR2ITGB2ICAM1 | |
| SCHEMBL2905026 | 0.98 | PYGL (0.44) | PYGLGPR183CCR2ITGB2ICAM1 | |
| SCHEMBL2904597 | 0.93 | CCR2 (0.44) | PYGLGPR183CCR2ITGB2ICAM1 | |
| SCHEMBL2902431 | 0.93 | GPR183 (0.48) | PYGLGPR183CCR2 | |
| SCHEMBL2902199 | 0.93 | GPR183 (0.48) | PYGLGPR183CCR2 | |
| SCHEMBL2902196 | 0.93 | GPR183 (0.48) | PYGLGPR183CCR2 | |
| SCHEMBL2902434 | 0.93 | GPR183 (0.48) | PYGLGPR183CCR2 | |
| SCHEMBL2902201 | 0.93 | GPR183 (0.48) | PYGLGPR183CCR2 | |
| SCHEMBL4243628 | 0.93 | GPR183 (0.48) | PYGLGPR183CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010506-B1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-04 | — | — | EP | disclosed |