Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 6/20 | 0.44 |
| ▸ | PYGL | P06737 | 2/20 | 0.44 |
| ▸ | GPR183 | P32249 | 4/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.40 |
| ▸ | ITGAL | P20701 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905026 | 0.95 | PYGL (0.44) | CCR2PYGLGPR183ITGB2ICAM1 | |
| SCHEMBL2897030 | 0.95 | CCR2 (0.47) | CCR2PYGLGPR183ITGB2ICAM1 | |
| SCHEMBL2897025 | 0.95 | CCR2 (0.47) | CCR2PYGLGPR183ITGB2ICAM1 | |
| SCHEMBL2904266 | 0.93 | PYGL (0.42) | CCR2PYGLGPR183ITGB2ICAM1 | |
| SCHEMBL2904263 | 0.93 | PYGL (0.42) | CCR2PYGLGPR183ITGB2ICAM1 | |
| SCHEMBL2904260 | 0.93 | PYGL (0.42) | CCR2PYGLGPR183ITGB2ICAM1 | |
| SCHEMBL2905016 | 0.93 | CCR2 (0.47) | CCR2PYGLGPR183ITGB2ICAM1 | |
| SCHEMBL2905012 | 0.93 | CCR2 (0.47) | CCR2PYGLGPR183ITGB2ICAM1 | |
| SCHEMBL2897314 | 0.92 | CCR2 (0.50) | CCR2PYGLGPR183 | |
| SCHEMBL2897119 | 0.91 | CCR2 (0.42) | CCR2PYGLGPR183ITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010506-B1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-04 | — | — | EP | disclosed |