Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL1903839 | 1.00 | TSHR (0.31) | TSHRATMATR | |
| Guanidine SCHEMBL56028 | 1.00 | — | — | |
| Guanidine SCHEMBL27473938 | 0.96 | — | — | |
| Guanidine SCHEMBL7755519 | 0.96 | — | — | |
| Guanidine SCHEMBL31206959 | 0.96 | — | — | |
| Guanidine SCHEMBL6529495 | 0.96 | — | — | |
| Guanidine SCHEMBL6851202 | 0.96 | — | — | |
| Guanidine SCHEMBL27492536 | 0.92 | — | — | |
| Guanidine SCHEMBL28453453 | 0.92 | — | — | |
| Guanidine SCHEMBL28312113 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110229806-B | Nanometer silicon dioxide coated trypsin and preparation method thereof | 上海大学 | 2023-05-16 | — | — | CN | disclosed |