Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL6529495 | 1.00 | — | — | |
| Guanidine SCHEMBL27473938 | 1.00 | — | — | |
| Guanidine SCHEMBL729040 | 0.96 | — | — | |
| Guanidine SCHEMBL27492536 | 0.96 | — | — | |
| Guanidine SCHEMBL56028 | 0.96 | — | — | |
| Guanidine SCHEMBL29044101 | 0.96 | TSHR (0.31) | — | |
| Guanidine SCHEMBL1903839 | 0.96 | TSHR (0.31) | — | |
| Guanidine SCHEMBL7755519 | 0.92 | — | — | |
| Guanidine SCHEMBL31206959 | 0.92 | — | — | |
| Guanidine SCHEMBL28453453 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114854827-A | Magnetic bead compound for enriching mRNA and application thereof | 苏州极客基因科技有限公司 | 2022-08-05 | — | — | CN | claimed |
| CN-111926059-A | Novel preservation solution for microbial nucleic acid in sputum | 广州源古纪科技有限公司 | 2020-11-13 | — | — | CN | claimed |
| US-12040049-B2 | Directional polymerisation fluorescent probe PCR and test kit | Jiang, Hong (CN) | 2024-07-16 | — | — | US | disclosed |
| CN-118240814-A | Purification method for completely distinguishing DNA and RNA purification kit | 中山大学 | 2024-06-25 | — | — | CN | disclosed |
| CN-111662962-B | Nucleic acid isothermal amplification method adopting bidirectional strand replacement loop circulation | 珠海市坤元科技有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-108774639-B | Directional polymerization fluorescent probe PCR | 澳門帝傑數碼基因有限公司 | 2023-05-30 | — | — | CN | disclosed |
| CN-114854827-A | Magnetic bead compound for enriching mRNA and application thereof | 苏州极客基因科技有限公司 | 2022-08-05 | — | — | CN | disclosed |
| CN-107075546-B | RNA-guided system for probing and mapping nucleic acids | 哈佛学院董事及会员团体 | 2021-08-31 | — | — | CN | disclosed |
| US-20210207204-A1 | DIRECTIONAL POLYMERISATION FLUORESCENT PROBE PCR AND TEST KIT | Jiang, Hong (CN) | 2021-07-08 | — | — | US | disclosed |
| CN-111926059-A | Novel preservation solution for microbial nucleic acid in sputum | 广州源古纪科技有限公司 | 2020-11-13 | — | — | CN | disclosed |
| CN-111662962-A | Nucleic acid isothermal amplification method adopting bidirectional strand replacement loop circulation | 珠海市坤元科技有限公司 | 2020-09-15 | — | — | CN | disclosed |
| US-6706493-B2 | NUCLEOTIDE SEQUENCES CODING POLYPEPTIDE FOR USE IN THE TREATMENT OF SCHIZOPHRENIA, PARKINSON'S, DRUG ADDICTION AND EATING DISORDERS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2004-03-16 | — | — | US | disclosed |
| US-20030055238-A1 | DNA ENCODING A CHOLECYSTOKININ RECEPTOR | WANK STEVEN A (US) | 2003-03-20 | — | — | US | disclosed |
| US-6169173-B1 | AMINO ACID AND NUCLEOTIDE SEQUENCES; FOR RECOMBINANT PRODUCTION | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2001-01-02 | — | — | US | disclosed |
| US-5319073-A | Passing the eluate of a a digitonin-solubilized, ion-exchanged sample through agarose-bound lectin and then through a cibacron blue sepharose column | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 1994-06-07 | — | — | US | disclosed |
| WO-1993016182-A1 | CLONING AND FUNCTIONAL EXPRESSION OF CHOLECYSTOKININ RECEPTOR-ENCODING DNA | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES (US) | 1993-08-19 | — | — | WO | disclosed |