Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL28838438 | 0.98 | TSHR (0.38) | TSHRNPSR1MEN1KMT2AHTT | |
| SCHEMBL2237645 | 0.91 | TSHR (0.42) | TSHRNPSR1MEN1KMT2AHTT | |
| SCHEMBL28838437 | 0.77 | ALDH1A1 (0.33) | ALDH1A1KDM4E | |
| Sulfuric Acid SCHEMBL28267131 | 0.71 | HSD17B10 (0.47) | TSHRNPSR1KMT2AMAPK1KDM4C | |
| SCHEMBL23382047 | 0.71 | HSD17B10 (0.54) | TSHRNPSR1KMT2AMAPK1KDM4C | |
| SCHEMBL21816183 | 0.71 | SMYD3 (0.45) | NPSR1KMT2AMAPK1KDM4CALDH1A1 | |
| SCHEMBL13941182 | 0.69 | NPSR1 (0.41) | TSHRNPSR1KMT2AMAPK1KDM4C | |
| SCHEMBL29217303 | 0.69 | NPSR1 (0.41) | TSHRNPSR1KMT2AMAPK1KDM4C | |
| SCHEMBL18572717 | 0.69 | NPSR1 (0.60) | TSHRNPSR1MEN1KMT2AMAPK1 | |
| SCHEMBL351234 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116514729-B | Preparation process of 1,2, 4-triazole-3-carboxylic acid methyl ester | 济南明鑫制药股份有限公司 | 2024-04-16 | — | — | CN | claimed |
| CN-116514729-A | Preparation process of 1,2, 4-triazole-3-carboxylic acid methyl ester | 济南明鑫制药股份有限公司 | 2023-08-01 | — | — | CN | claimed |
| CN-116514729-B | Preparation process of 1,2, 4-triazole-3-carboxylic acid methyl ester | 济南明鑫制药股份有限公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-116514729-A | Preparation process of 1,2, 4-triazole-3-carboxylic acid methyl ester | 济南明鑫制药股份有限公司 | 2023-08-01 | — | — | CN | disclosed |