Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25360362 | 0.83 | GSK3B (0.40) | HPGDGSK3BHDAC6HDAC3HDAC4 | |
| SCHEMBL16746890 | 0.81 | ALOX5 (0.46) | HPGDMAOACYP1A2CYP3A4LMNA | |
| SCHEMBL29045244 | 0.79 | TSHR (0.38) | HPGDMAOACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL29045259 | 0.79 | GABBR2 (0.43) | HPGDGSK3BLMNATSHRSMN1; SMN2 | |
| SCHEMBL24345842 | 0.79 | GAA (0.43) | HPGDMAOACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7759137 | 0.78 | CYP2C9 (0.65) | HPGDADRA2CMAOAADRA1ADRD3 | |
| SCHEMBL29045300 | 0.76 | DAO (0.41) | HPGDHDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL19216452 | 0.76 | GSK3B (0.46) | HPGDADRA2CMAOAADRA1ADRD3 | |
| SCHEMBL3175959 | 0.75 | LMNA (0.48) | HPGDADRA2CMAOAADRA1ADRD3 | |
| SCHEMBL3253491 | 0.74 | HDAC3 (0.65) | HPGDMAOACYP1A2CYP3A4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547287-A | Inhibitors of APOL1 and methods of use thereof | 弗特克斯药品有限公司 | 2023-08-04 | — | — | CN | disclosed |