Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 2/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29985926 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9ATP53FOXM1 | |
| SCHEMBL29985574 | 0.86 | FOXM1 (0.55) | SMN1; SMN2NPC1RAB9ATP53FOXM1 | |
| SCHEMBL29986797 | 0.84 | F2 (0.70) | SMN1; SMN2NPC1RAB9ATP53FOXM1 | |
| SCHEMBL29986882 | 0.79 | FOXM1 (0.61) | SMN1; SMN2NPC1RAB9ATP53FOXM1 | |
| SCHEMBL6852321 | 0.77 | LMNA (0.64) | SMN1; SMN2NPC1RAB9ATP53FOXM1 | |
| SCHEMBL29045836 | 0.76 | FOXM1 (0.52) | SMN1; SMN2NPC1RAB9ATP53FOXM1 | |
| SCHEMBL29045841 | 0.74 | FOXM1 (0.63) | SMN1; SMN2NPC1RAB9ATP53FOXM1 | |
| SCHEMBL29045793 | 0.73 | APP (0.60) | SMN1; SMN2NPC1RAB9ATP53FOXM1 | |
| SCHEMBL29045855 | 0.73 | FOXM1 (0.55) | SMN1; SMN2NPC1RAB9ATP53FOXM1 | |
| SCHEMBL1160957 | 0.72 | HTT (0.64) | SMN1; SMN2NPC1RAB9AF2GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304502-A | FOXM1 inhibitor and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2022-11-08 | — | — | CN | disclosed |