Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 9/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.70 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29986882 | 0.90 | FOXM1 (0.61) | F2KCNH2GRIN2BFOXM1TP53 | |
| SCHEMBL29045855 | 0.84 | FOXM1 (0.55) | F2KCNH2GRIN2BFOXM1TP53 | |
| SCHEMBL29045793 | 0.84 | APP (0.60) | F2KCNH2GRIN2BFOXM1TP53 | |
| SCHEMBL29045774 | 0.84 | SMN1; SMN2 (0.54) | F2KCNH2GRIN2BFOXM1TP53 | |
| SCHEMBL29985926 | 0.84 | SMN1; SMN2 (0.54) | F2KCNH2GRIN2BFOXM1TP53 | |
| SCHEMBL29985574 | 0.82 | FOXM1 (0.55) | F2KCNH2GRIN2BFOXM1TP53 | |
| SCHEMBL6672805 | 0.80 | F2 (0.68) | F2KCNH2GRIN2B | |
| SCHEMBL12443081 | 0.80 | F2 (0.89) | F2KCNH2GRIN2BTP53SMN1; SMN2 | |
| SCHEMBL6852321 | 0.80 | LMNA (0.64) | FOXM1TP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7316316 | 0.79 | F2 (1.00) | F2KCNH2GRIN2BTP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304502-B | FOXM1 inhibitor and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2024-10-18 | — | — | CN | disclosed |
| CN-115304502-A | FOXM1 inhibitor and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2022-11-08 | — | — | CN | disclosed |