Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.64 |
| ▸ | CSF1R | P07333 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 4/20 | 0.60 |
| ▸ | THRB | P10828 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081004 | 0.91 | MAPT (0.58) | MAPTCSF1RGAATHRBTP53 | |
| SCHEMBL2913279 | 0.91 | CSF1R (0.64) | MAPTCSF1RGAATHRBTP53 | |
| SCHEMBL23575246 | 0.90 | MAPT (0.61) | MAPTGAATHRBTP53SMN1; SMN2 | |
| SCHEMBL2912196 | 0.89 | CSF1R (0.64) | MAPTCSF1RGAATHRBTP53 | |
| SCHEMBL2909819 | 0.88 | MAPT (0.72) | MAPTCSF1RGAATHRBTP53 | |
| SCHEMBL2905486 | 0.88 | MAPT (0.67) | MAPTCSF1RGAATHRBMEN1 | |
| SCHEMBL2908163 | 0.87 | CSF1R (0.64) | MAPTCSF1RGAATHRBTP53 | |
| SCHEMBL2913350 | 0.84 | MAPT (0.59) | MAPTGAATHRBTP53SMN1; SMN2 | |
| SCHEMBL2910297 | 0.84 | MAPT (0.59) | MAPTCSF1RGAATHRBTP53 | |
| SCHEMBL2913881 | 0.84 | CSF1R (0.65) | MAPTCSF1RGAATHRBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |