Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.55 |
| ▸ | GAA | P10253 | 7/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | MC4R | P32245 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081004 | 0.93 | MAPT (0.58) | MAPTTP53SMN1; SMN2GAAPAX8 | |
| SCHEMBL2912034 | 0.89 | AURKB (0.59) | MAPTTP53SMN1; SMN2AURKBAURKA | |
| SCHEMBL2907589 | 0.89 | MAPT (0.66) | MAPTTP53SMN1; SMN2GAAPAX8 | |
| SCHEMBL2904906 | 0.87 | MAPT (0.58) | MAPTTP53SMN1; SMN2GAAPAX8 | |
| SCHEMBL2910608 | 0.86 | AURKB (0.61) | MAPTTP53SMN1; SMN2GAAAURKB | |
| SCHEMBL2912397 | 0.85 | CA2 (0.61) | MAPTTP53SMN1; SMN2GAALMNA | |
| SCHEMBL2908274 | 0.85 | CA2 (0.61) | MAPTTP53SMN1; SMN2GAAPAX8 | |
| SCHEMBL2913228 | 0.85 | MAPT (0.61) | MAPTTP53SMN1; SMN2AURKBHTT | |
| SCHEMBL2904593 | 0.84 | MAPT (0.64) | MAPTTP53SMN1; SMN2GAAPAX8 | |
| SCHEMBL23575246 | 0.84 | MAPT (0.61) | MAPTTP53SMN1; SMN2GAAPAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |