Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.39 |
| ▸ | ALKBH1 | Q13686 | 2/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29047802 | 0.85 | GRM2 (0.42) | L3MBTL1KLKB1MEN1KMT2A | |
| SCHEMBL31075223 | 0.83 | GRM2 (0.44) | POLBTDP1MEN1KMT2A | |
| SCHEMBL1912400 | 0.75 | HSD17B10 (0.77) | L3MBTL1HSD17B10POLBTDP1KLKB1 | |
| SCHEMBL553830 | 0.75 | L3MBTL1 (0.62) | L3MBTL1HSD17B10POLBTDP1ALKBH1 | |
| SCHEMBL31075273 | 0.75 | L3MBTL1 (0.46) | L3MBTL1HSD17B10POLBTDP1EGLN1 | |
| SCHEMBL948453 | 0.75 | HSD17B10 (0.61) | L3MBTL1HSD17B10POLBTDP1KLKB1 | |
| SCHEMBL15520232 | 0.74 | HSD17B10 (0.54) | L3MBTL1HSD17B10POLBTDP1PLA2G4A | |
| SCHEMBL19299982 | 0.74 | HSD17B10 (0.65) | L3MBTL1HSD17B10POLBTDP1PLA2G4A | |
| SCHEMBL16246805 | 0.74 | KLKB1 (0.62) | L3MBTL1HSD17B10POLBTDP1KLKB1 | |
| SCHEMBL4019778 | 0.73 | HSD17B10 (0.72) | L3MBTL1HSD17B10POLBTDP1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665330-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173196-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-08-22 | — | — | WO | disclosed |
| CN-116157154-A | Plasma kallikrein inhibitors | 默沙东有限责任公司 | 2023-05-23 | — | — | CN | disclosed |
| EP-4178620-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-05-17 | — | — | EP | disclosed |