Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | FOS | P01100 | 1/20 | 0.38 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29047802 | 0.87 | GRM2 (0.42) | GRM2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL29047870 | 0.83 | L3MBTL1 (0.51) | MEN1KMT2APOLBTDP1 | |
| SCHEMBL2818630 | 0.82 | GRM2 (0.48) | GRM2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL1909166 | 0.80 | GRM2 (0.53) | GRM2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL31075230 | 0.80 | POLB (0.44) | GRM2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL2821953 | 0.79 | LMNA (0.54) | GRM2MAPTALDH1A1TDP1LMNA | |
| SCHEMBL28595790 | 0.79 | ESR1 (0.55) | GRM2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL553848 | 0.79 | ALDH1A1 (0.60) | GRM2ALDH1A1TDP1LMNATSHR | |
| SCHEMBL3101067 | 0.79 | KMT2A (0.51) | GRM2MEN1KMT2AKDM4EMAPT | |
| SCHEMBL18795048 | 0.79 | GRM2 (0.55) | GRM2MAPTALDH1A1POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665330-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173196-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-08-22 | — | — | WO | disclosed |