Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.37 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CD74 | P04233 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31075223 | 0.87 | GRM2 (0.44) | GRM2HPGDMEN1KMT2AKDM4E | |
| SCHEMBL29047870 | 0.85 | L3MBTL1 (0.51) | MEN1KMT2AKLKB1L3MBTL1 | |
| SCHEMBL18794996 | 0.78 | GRM2 (0.53) | GRM2HPGDMEN1TP53KMT2A | |
| SCHEMBL3765456 | 0.78 | KLKB1 (0.53) | KLKB1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL23773968 | 0.76 | BTK (0.54) | GRM2KLKB1 | |
| SCHEMBL29117303 | 0.76 | GRM2 (0.61) | GRM2TP53KLKB1KDM4EALDH1A1 | |
| SCHEMBL17895755 | 0.76 | L3MBTL1 (0.60) | GRM2HPGDMEN1TP53KMT2A | |
| SCHEMBL2221944 | 0.75 | MAPK1 (0.52) | TP53KDM4EALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL2187671 | 0.74 | L3MBTL1 (0.45) | GRM2HPGDKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL21375878 | 0.73 | GRM2 (0.54) | GRM2HPGDMEN1TP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665330-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173196-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-08-22 | — | — | WO | disclosed |
| CN-116157154-A | Plasma kallikrein inhibitors | 默沙东有限责任公司 | 2023-05-23 | — | — | CN | disclosed |