Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Z-Butylidenephthalide SCHEMBL30268972 | 1.00 | TRPA1 (1.00) | TRPA1ALDH1A1TSHRMAPK1KDM4E | |
| Z-Butylidenephthalide SCHEMBL290483 | 1.00 | TRPA1 (1.00) | TRPA1ALDH1A1TSHRMAPK1KDM4E | |
| Z-Butylidenephthalide SCHEMBL27581583 | 1.00 | TRPA1 (1.00) | TRPA1ALDH1A1TSHRMAPK1KDM4E | |
| Z-Butylidenephthalide SCHEMBL29372485 | 1.00 | TRPA1 (1.00) | TRPA1ALDH1A1TSHRMAPK1KDM4E | |
| (E)-Butylidenephthalide SCHEMBL783051 | 1.00 | TRPA1 (1.00) | TRPA1ALDH1A1TSHRMAPK1KDM4E | |
| Z-Butylidenephthalide SCHEMBL28057404 | 1.00 | TRPA1 (1.00) | TRPA1ALDH1A1TSHRMAPK1KDM4E | |
| Z-Butylidenephthalide SCHEMBL27312198 | 0.98 | TRPA1 (0.96) | TRPA1ALDH1A1TSHRMAPK1KDM4E | |
| Z-Butylidenephthalide SCHEMBL28057401 | 0.92 | TRPA1 (0.84) | TRPA1ALDH1A1TSHRMAPK1KDM4E | |
| SCHEMBL6530791 | 0.89 | TRPA1 (0.81) | TRPA1ALDH1A1TSHRMAPK1KDM4E | |
| Z-Butylidenephthalide SCHEMBL28165145 | 0.89 | TRPA1 (0.79) | TRPA1ALDH1A1TSHRMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 314 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250295123-A1 | Arthropod Control Compositions | FIRMENICH & CIE (CH) | 2025-09-25 | — | — | US | claimed |
| US-20230247992-A1 | ARTHROPOD CONTROL COMPOSITION | FIRMENICH & CIE (CH) | 2023-08-10 | — | — | US | claimed |
| WO-2023117960-A1 | ARTHROPOD CONTROL COMPOSITIONS | FIRMENICH SA (CH) | 2023-06-29 | — | — | WO | claimed |
| EP-4181681-A1 | ARTHROPOD CONTROL COMPOSITION | Firmenich SA (CH) | 2023-05-24 | — | — | EP | claimed |
| CN-115867139-A | Arthropod control composition | 弗门尼舍有限公司 | 2023-03-28 | — | — | CN | claimed |
| CN-114989891-A | Angelica essential oil and preparation method and application thereof | 湖南诺泽生物科技有限公司 | 2022-09-02 | — | — | CN | claimed |
| WO-2022013204-A1 | ARTHROPOD CONTROL COMPOSITION | FIRMENICH SA (CH) | 2022-01-20 | — | — | WO | claimed |
| CN-109069478-B | Application of Z-butylidene phthalide in activating autoimmune system | 长弘生物科技股份有限公司 | 2021-07-06 | — | — | CN | claimed |
| EP-3208267-B1 | METHOD FOR PREPARING ISOBENZOFURAN-1(3H)-ONE COMPOUND | EVERFRONT BIOTECH INC (TW) | 2020-12-23 | — | — | EP | claimed |
| EP-3466422-B1 | USE OF Z-BUTYLIDENEPHTHALIDE IN ACTIVATING AUTOIMMUNE SYSTEM | EVERFRONT BIOTECH INC (TW) | 2020-11-18 | — | — | EP | claimed |
| CN-102579434-B | pharmaceutical composition for treating brain cancer or for reducing resistance of brain cancer cells to temozolomide | UNIV CHINA MEDICAL | 2014-03-19 | — | — | CN | claimed |
| EP-2621462-A1 | ORAL CARE COMPOSITIONS WITH IMPROVED FLAVOR | The Procter and Gamble Company (US) | 2013-08-07 | — | — | EP | claimed |
| EP-2438914-B1 | Pharmaceutical composition comprising Z-butylidenephthalide for treating brain cancer or reducing temozolomide-resistance of brain cancer cells | UNIV CHINA MEDICAL (TW) | 2013-05-08 | — | — | EP | claimed |
| CN-102579434-A | Pharmaceutical composition for treating brain cancer or for reducing resistance of brain cancer cells to temozolomide | UNIV CHINA MEDICAL | 2012-07-18 | — | — | CN | claimed |
| US-20120178803-A1 | METHOD FOR TREATING BRAIN CANCER OR REDUCING TEMOZOLOMIDE-RESISTANCE OF BRAIN CANCER CELLS | CHINA MEDICAL UNIVERSITY (TW) | 2012-07-12 | — | — | US | claimed |
| WO-2012044728-A1 | ORAL CARE COMPOSITIONS WITH IMPROVED FLAVOR | THE PROCTER & GAMBLE COMPANY (US) | 2012-04-05 | — | — | WO | claimed |
| US-20120082628-A1 | Oral Care Compositions With Improved Flavor | THE PROCTER & GAMBLE COMPANY | 2012-04-05 | — | — | US | claimed |
| EP-2343051-A2 | Anti-cancer formulation | National Dong Hwa University (TW) | 2011-07-13 | — | — | EP | claimed |
| US-20110165201-A1 | ANTICANCER FORMULATION | NATIONAL DONG HWA UNIVERSITY (TW) | 2011-07-07 | — | — | US | claimed |
| CN-1041725-C | Method for synthetising 3-butenyl phthalide | UNIV LANZHOU (CN) | 1999-01-20 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178803-A1 | METHOD FOR TREATING BRAIN CANCER OR REDUCING TEMOZOLOMIDE-RESISTANCE OF BRAIN CANCER CELLS | MGMT, SLC11A2, GABARAPL2 | TRPA1 4405/4885ALDH1A1 1034/4885TSHR 2943/4885 |
| US-20120082628-A1 | Oral Care Compositions With Improved Flavor | TRPA1, TAS2R40, TAS2R30 | TRPA1 1/4885ALDH1A1 1558/4885TSHR 1962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.