Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR6 | P46095 | 6/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22256508 | 0.86 | TNKS (0.34) | TNKSCHRNB2CHRNA4 | |
| SCHEMBL22444813 | 0.86 | TNKS (0.34) | TNKSCHRNB2CHRNA4 | |
| SCHEMBL18921404 | 0.86 | TNKS (0.34) | TNKSCHRNB2CHRNA4 | |
| SCHEMBL29966596 | 0.86 | TNKS (0.34) | TNKSCHRNB2CHRNA4 | |
| SCHEMBL29641343 | 0.86 | TNKS (0.34) | TNKSCHRNB2CHRNA4 | |
| Trifluoroacetic Acid SCHEMBL18921382 | 0.86 | JAK2 (0.32) | KDM1ACHRNB2CHRNA4 | |
| Trifluoroacetic Acid SCHEMBL29966503 | 0.86 | JAK2 (0.32) | KDM1ACHRNB2CHRNA4 | |
| Trifluoroacetic Acid SCHEMBL30338680 | 0.85 | GABRP (0.36) | KDM1ATNKSPDE3BPDE3AKCNH2 | |
| Trifluoroacetic Acid SCHEMBL31205908 | 0.81 | ABL1 (0.32) | PDE3BPDE3ACHRNB2CHRNA4 | |
| Trifluoroacetic Acid SCHEMBL30338646 | 0.79 | CHRNB2 (0.33) | KDM1ACHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | disclosed |