Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | KDM1A | O60341 | 3/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL18921382 | 1.00 | JAK2 (0.32) | JAK2JAK1KDM1ACHRNB2CHRNA4 | |
| SCHEMBL18921312 | 0.87 | CHRNB2 (0.31) | CHRNB2CHRNA4KMT2ATDP1 | |
| SCHEMBL29966900 | 0.87 | CHRNB2 (0.31) | CHRNB2CHRNA4KMT2ATDP1 | |
| SCHEMBL29966490 | 0.87 | CHRNB2 (0.31) | CHRNB2CHRNA4KMT2ATDP1 | |
| SCHEMBL18921319 | 0.87 | CHRNB2 (0.31) | CHRNB2CHRNA4KMT2ATDP1 | |
| Trifluoroacetic Acid SCHEMBL29048254 | 0.86 | GPR6 (0.33) | KDM1ACHRNB2CHRNA4 | |
| Trifluoroacetic Acid SCHEMBL30338680 | 0.86 | GABRP (0.36) | JAK2KDM1AKDM4EGLAHTT | |
| Trifluoroacetic Acid SCHEMBL31205908 | 0.80 | ABL1 (0.32) | CHRNB2CHRNA4 | |
| Trifluoroacetic Acid SCHEMBL30338646 | 0.80 | CHRNB2 (0.33) | KDM1ACHRNB2CHRNA4 | |
| Trifluoroacetic Acid SCHEMBL30581170 | 0.78 | CHRNB2 (0.33) | KDM1ACHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602809-B | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1(RIPK 1) | 戴纳立制药公司 | 2022-09-30 | — | — | CN | disclosed |