Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 7/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | CHRNG | P07510 | 1/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.37 |
| ▸ | CHRND | Q07001 | 1/20 | 0.37 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.32 |
| ▸ | FASN | P49327 | 1/20 | 0.32 |
| ▸ | CPT1A | P50416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29048260 | 1.00 | RIPK1 (0.50) | RIPK1PIK3CDPIK3CACHRNA1CHRNB4 | |
| SCHEMBL25816557 | 0.87 | RIPK1 (0.48) | RIPK1PIK3CDPIK3CACHRNA1CHRNB4 | |
| SCHEMBL29048252 | 0.86 | RIPK1 (0.43) | RIPK1CHRNA1CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL18921452 | 0.86 | RIPK1 (0.43) | RIPK1CHRNA1CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL25303343 | 0.85 | GPR119 (0.49) | RIPK1GPR119 | |
| SCHEMBL30338800 | 0.85 | GPR119 (0.49) | RIPK1GPR119 | |
| SCHEMBL30338852 | 0.84 | RIPK1 (0.42) | RIPK1PIK3CDPIK3CACHRNA1CHRNB4 | |
| SCHEMBL31205667 | 0.84 | RIPK1 (0.52) | RIPK1 | |
| SCHEMBL31196395 | 0.83 | RIPK1 (0.46) | RIPK1PIK3CDPIK3CACHRNA1CHRNB4 | |
| SCHEMBL31200215 | 0.83 | RIPK1 (0.46) | RIPK1PIK3CDPIK3CACHRNA1CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |