Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 7/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.38 |
| ▸ | CHRNG | P07510 | 1/20 | 0.38 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.38 |
| ▸ | CHRND | Q07001 | 1/20 | 0.38 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25818710 | 0.96 | RIPK1 (0.46) | RIPK1KDM1ACHRNB4CHRNA3CHRNB2 | |
| Trifluoroacetic Acid SCHEMBL25251798 | 0.93 | RIPK1 (0.46) | RIPK1KDM1ACHRNB4CHRNA3CHRNB2 | |
| Trifluoroacetic Acid SCHEMBL30339096 | 0.93 | RIPK1 (0.46) | RIPK1KDM1ACHRNB4CHRNA3CHRNB2 | |
| Trifluoroacetic Acid SCHEMBL29048342 | 0.93 | RIPK1 (0.46) | RIPK1KDM1ACHRNB4CHRNA3CHRNB2 | |
| SCHEMBL31196305 | 0.89 | RIPK1 (0.46) | RIPK1KDM1ACHRNB4CHRNA3CHRNB2 | |
| SCHEMBL31200215 | 0.89 | RIPK1 (0.46) | RIPK1KDM1ACHRNB4CHRNA3CHRNB2 | |
| SCHEMBL31196395 | 0.89 | RIPK1 (0.46) | RIPK1KDM1ACHRNB4CHRNA3CHRNB2 | |
| SCHEMBL29048260 | 0.87 | RIPK1 (0.50) | RIPK1CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL29048261 | 0.87 | RIPK1 (0.50) | RIPK1CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL18921452 | 0.85 | RIPK1 (0.43) | RIPK1CHRNB4CHRNA3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219937-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219937-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | RIPK1, RIPK4, RIPK2 | RIPK1 1/4885KDM1A 798/4885CHRNB4 4475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.