Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.34 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.34 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.33 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL30339096 | 1.00 | RIPK1 (0.46) | RIPK1KDM1ACHRNB2CHRNA4CHRNA3 | |
| Trifluoroacetic Acid SCHEMBL25251798 | 1.00 | RIPK1 (0.46) | RIPK1KDM1ACHRNB2CHRNA4CHRNA3 | |
| SCHEMBL25816557 | 0.93 | RIPK1 (0.48) | RIPK1KDM1ACHRNB2CHRNA4CHRNA3 | |
| SCHEMBL25818710 | 0.89 | RIPK1 (0.46) | RIPK1KDM1ACHRNB2CHRNA4CHRNA3 | |
| Trifluoroacetic Acid SCHEMBL30799090 | 0.86 | RIPK1 (0.59) | RIPK1KDM1A | |
| Trifluoroacetic Acid SCHEMBL30339113 | 0.85 | RIPK1 (0.42) | RIPK1KDM1ACHRNB2CHRNA4CHRNA3 | |
| Trifluoroacetic Acid SCHEMBL30338761 | 0.85 | RIPK1 (0.36) | RIPK1CHRNB2CHRNA4CHRNA3CHRNB3 | |
| Trifluoroacetic Acid SCHEMBL25256183 | 0.85 | RIPK1 (0.36) | RIPK1CHRNB2CHRNA4CHRNA3CHRNB3 | |
| SCHEMBL31196305 | 0.82 | RIPK1 (0.46) | RIPK1KDM1ACHRNB2CHRNA4CHRNA3 | |
| SCHEMBL31196395 | 0.82 | RIPK1 (0.46) | RIPK1KDM1ACHRNB2CHRNA4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |