Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 11/20 | 0.59 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30420762 | 0.94 | RIPK1 (0.65) | RIPK1KDM1ATRPM5MGLL | |
| SCHEMBL25190408 | 0.94 | RIPK1 (0.65) | RIPK1KDM1ATRPM5MGLL | |
| Trifluoroacetic Acid SCHEMBL30339077 | 0.91 | RIPK1 (0.53) | RIPK1KDM1ADPP4DPP7 | |
| Trifluoroacetic Acid SCHEMBL30339096 | 0.86 | RIPK1 (0.46) | RIPK1KDM1A | |
| Trifluoroacetic Acid SCHEMBL25251798 | 0.86 | RIPK1 (0.46) | RIPK1KDM1A | |
| Trifluoroacetic Acid SCHEMBL29048342 | 0.86 | RIPK1 (0.46) | RIPK1KDM1A | |
| SCHEMBL31196345 | 0.84 | RIPK1 (0.64) | RIPK1TRPM5MGLL | |
| SCHEMBL25816765 | 0.84 | RIPK1 (0.58) | RIPK1KDM1A | |
| SCHEMBL25691604 | 0.84 | RIPK1 (0.58) | RIPK1KDM1A | |
| SCHEMBL31196299 | 0.84 | RIPK1 (0.61) | RIPK1KDM1ATRPM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4573090-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2025-06-25 | — | — | EP | disclosed |
| WO-2024040155-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-02-22 | — | — | WO | disclosed |