SCHEMBL29048643

SCHEMBL29048643

COc1ccc(-c2cc(-c3ccc(Nc4ccc(C(C)(C)C)cc4)cc3)ccn2)c(OC)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR2 P21802 8/20 0.50
CCR9 P51686 1/20 0.42
TGFBR1 P36897 1/20 0.42
CSNK2A1 P68400 1/20 0.42
AKR1C3 P42330 1/20 0.41
AKR1C2 P52895 1/20 0.41
CYP1A1 P04798 2/20 0.41
CYP1B1 Q16678 2/20 0.41
GSK3B P49841 1/20 0.41
PDGFRB P09619 1/20 0.40
KIT P10721 1/20 0.40
PDGFRA P16234 1/20 0.40
KDR P35968 1/20 0.40
CCNT1 O60563 1/20 0.40
CDK9 P50750 1/20 0.40
DYRK1A Q13627 1/20 0.39
MEN1 O00255 1/20 0.39
NPC1 O15118 1/20 0.39
MAPT P10636 1/20 0.39
NFKB1 P19838 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29048655 0.87 FGFR2 (0.50) FGFR2TGFBR1CSNK2A1CYP1A1CYP1B1
SCHEMBL21670550 0.87 FGFR2 (0.45) FGFR2CSNK2A1AKR1C3AKR1C2CYP1A1
SCHEMBL30525978 0.87 FGFR2 (0.45) FGFR2CSNK2A1AKR1C3AKR1C2CYP1A1
SCHEMBL29048645 0.86 DYRK1A (0.43) FGFR2CCR9TGFBR1CYP1A1CYP1B1
SCHEMBL29048683 0.85 FGFR2 (0.41) FGFR2TGFBR1GSK3BPDGFRBKIT
SCHEMBL29048632 0.79 MAPT (0.43) FGFR2TGFBR1KDRDYRK1ANPC1
SCHEMBL29048613 0.78 MAPK10 (0.44) FGFR2TGFBR1CCNT1CDK9
SCHEMBL17144531 0.78 CYP1A1 (0.60) TGFBR1CYP1A1CYP1B1KITMEN1
SCHEMBL12297227 0.76 CSNK2A1 (0.70) CSNK2A1CYP1A1CYP1B1MEN1NPC1
SCHEMBL1623731 0.75 CYP1A1 (0.59) CYP1A1CYP1B1MAPTNFKB1NFKB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110446770-B Reversible thermochromic composition and reversible thermochromic microcapsule pigment containing the same 百乐墨水株式会社 2023-08-08 CN disclosed