SCHEMBL29048645

SCHEMBL29048645

COc1ccc(-c2cc(-c3ccc(-c4ccc(C(C)(C)C)cc4)cc3N)ccn2)c(OC)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 2/20 0.43
CDC7 O00311 2/20 0.41
CYP1A1 P04798 5/20 0.40
CYP1B1 Q16678 5/20 0.40
CYP1A2 P05177 2/20 0.39
CYP2E1 P05181 2/20 0.39
CYP3A4 P08684 2/20 0.39
CYP2C8 P10632 2/20 0.39
CYP2D6 P10635 2/20 0.39
CYP2A6 P11509 2/20 0.39
CYP2C9 P11712 2/20 0.39
CYP4B1 P13584 2/20 0.39
CYP2B6 P20813 2/20 0.39
CYP3A5 P20815 2/20 0.39
CYP2A7 P20853 2/20 0.39
CYP3A7 P24462 2/20 0.39
CYP2F1 P24903 2/20 0.39
CYP2C18 P33260 2/20 0.39
CYP2C19 P33261 2/20 0.39
CYP2J2 P51589 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29048643 0.86 FGFR2 (0.50) DYRK1ACYP1A1CYP1B1MEN1KMT2A
SCHEMBL29048684 0.85 MAPT (0.36) DYRK1ACYP3A4CYP2C9CYP2C19MEN1
SCHEMBL29048617 0.80 PTPRC (0.41) ADORA1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL17144531 0.79 CYP1A1 (0.60) CDC7CYP1A1CYP1B1CYP1A2CYP2E1
SCHEMBL29048636 0.79 DYRK1A (0.47) DYRK1AMEN1KMT2ANPC1MAPT
SCHEMBL29048671 0.77 ALOX5AP (0.46) DYRK1ACYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL29048651 0.76 KIF11 (0.33) CDC7ALOX5APFEN1
SCHEMBL29048681 0.75 KDM4E (0.41) DYRK1ACYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL29048625 0.74 MEN1 (0.36) DYRK1AMEN1KMT2ANPC1MAPT
SCHEMBL1623731 0.74 CYP1A1 (0.59) CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110446770-B Reversible thermochromic composition and reversible thermochromic microcapsule pigment containing the same 百乐墨水株式会社 2023-08-08 CN disclosed