Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | WDR5 | P61964 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10127604 | 0.89 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL30736225 | 0.89 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL21808580 | 0.89 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL16501054 | 0.89 | LMNA (0.51) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL12525222 | 0.87 | KMT2A (0.54) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL29556577 | 0.84 | ALDH1A1 (0.64) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL2062270 | 0.84 | ALDH1A1 (0.64) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL30879319 | 0.84 | CYP19A1 (0.54) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL2910168 | 0.83 | HTT (0.47) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL30879346 | 0.83 | CYP19A1 (0.45) | ALDH1A1LMNAMAPTMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010496-B1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-08-25 | — | — | EP | disclosed |
| CN-101466682-A | 4-anilinoquinolina-3-carboxamidas como inhibidores de la quinasa CSF-1R | ASTRAZENECA AB (SE) | 2009-06-24 | — | — | CN | disclosed |
| US-20090054411-A1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054411-A1 | 4-ANILINOQUINOLINE-3-CARBOXAMIDES AS CSF-1R KINASE INHIBITORS | CSF1R, CSF3R, FLT3 | ALDH1A1 1650/4885LMNA 3715/4885MAPT 3289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.