Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30879090 | 0.99 | CYP19A1 (0.47) | CYP19A1ALDH1A1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL30879417 | 0.95 | CYP19A1 (0.44) | CYP19A1ALDH1A1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL30879164 | 0.89 | CYP19A1 (0.54) | CYP19A1ALDH1A1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL16501054 | 0.84 | LMNA (0.51) | CYP19A1ALDH1A1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL30310801 | 0.83 | HTT (0.43) | ALDH1A1LMNASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL2904916 | 0.83 | ALDH1A1 (0.51) | ALDH1A1LMNASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL30879277 | 0.81 | NFE2L2 (0.50) | ALDH1A1HTTGAAACHEKDM4E | |
| SCHEMBL30879017 | 0.81 | CYP19A1 (0.53) | CYP19A1ALDH1A1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL30878933 | 0.80 | NFE2L2 (0.52) | ALDH1A1HTTGAAACHEKDM4E | |
| SCHEMBL26644425 | 0.80 | ALDH1A1 (0.48) | ALDH1A1LMNASMN1; SMN2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |